PDE11A 抗体 (Internal Region)
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Quick Overview for PDE11A 抗体 (Internal Region) (ABIN374774)
抗原
See all PDE11A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody reacts to PDE11A.
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交叉反应 （详细）
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Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Peptide with sequence C-NSFKESMEKSSYSD, from the internal region of the protein sequence
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anti-phosphodiesterase 11A (PDE11A) (AA 42-190) antibody
PDE11A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 11A (PDE11A) (Internal Region) antibodyVerified PDE11A 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-phosphodiesterase 11A (PDE11A) (Internal Region) antibodyPDE11A 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 斑马鱼, Bat, 猴, Pig, 小鸡, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 11A (PDE11A) (AA 712-933) antibodyPDE11A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Peptide ELISA: 1/2000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PDE11A (phosphodiesterase 11A (PDE11A))
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别名
- PDE11A
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背景
- One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP, it is sensitive to non selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis. There are several isoforms known: Isoform 1 is present in prostate, pituitary, heart and liverbut not in testis or in penis. Isoform 2 is believed to be expressed in testis and Isoform 4 in the adrenal cortex.Synonyms: 5'-cyclic-AMP and -GMP phosphodiesterase 11A, Dual 3', PDE11A1, PDE11A2, PDE11A3, PDE11A4, Phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A
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基因ID
- 50940
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NCBI登录号
- NP_001070664
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UniProt
- Q9HCR9
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途径
- cAMP Metabolic Process
抗原
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