PPID 抗体 (Internal Region)
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Quick Overview for PPID 抗体 (Internal Region) (ABIN374769)
抗原
See all PPID 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody reacts to PPID / CyP-40.
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交叉反应 （详细）
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Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Peptide with sequence C-DENFHYKHDREG, from the internal region of the protein sequence
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anti-Peptidylprolyl Isomerase D (PPID) (AA 7-206) antibody
PPID 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Isomerase D (PPID) (AA 161-370) antibodyPPID 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Isomerase D (PPID) (AA 336-370) antibodyPPID 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB55961 unconjugated
anti-Peptidylprolyl Isomerase D (PPID) (AA 1-370) antibodyPPID 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Peptidylprolyl Isomerase D (PPID) antibodyPPID 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Isomerase D (PPID) (AA 1-370) antibodyPPID 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C7 unconjugated
anti-Peptidylprolyl Isomerase D (PPID) (AA 9-189) antibodyPPID 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Isomerase D (PPID) (AA 7-191) antibodyPPID 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Isomerase D (PPID) antibodyKD Validated PPID 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB1560 unconjugated Recombinant Antibody
anti-Peptidylprolyl Isomerase D (PPID) (AA 1-370) antibodyPPID 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Peptide ELISA: 1/64000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PPID (Peptidylprolyl Isomerase D (PPID))
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别名
- Cyclophilin-40
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背景
- Cyclophilin 40 is a widely expressed member of the cyclophilin type PPIase family, PPIase D subfamily. It contains 1 PPIase cyclophilin type domain and 3 TPR repeats. It catalyzes the cis trans isomerization of proline imidic peptide bonds in oligopeptides. and has a role in accelerating the folding of proteins. It is less sensitive to inhibition by cyclosporin A than CYP18. Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyP-40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP-18) and FKBP59. CyP-40 exhibits the characteristic CsA binding and isomerase activity of CyP-18, though these activities appear to be less with CyP-40 than with Cyp-18. Like FKBP59, CyP-40 has been found in progesterone receptor complexes. CyP-40 is expressed at similar levels in many tissues.Synonyms: 40 kDa peptidyl-prolyl cis-trans isomerase, CYP-40, CYP40, CYPD, Cyclophilin D, Cyclophilin-related protein, PPID, PPIase D, Rotamase D
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基因ID
- 5481, 9606
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UniProt
- Q08752
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途径
- Nuclear Hormone Receptor Binding
抗原
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