FTCD 抗体 (Internal Region)
Our Local Distributor
北京 101111
Quick Overview for FTCD 抗体 (Internal Region) (ABIN374454)
抗原
See all FTCD 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
序列
- CLREQGRGKD QPGRL
-
特异性
- This antibody recognizes 58KGolgi protein (Internal).
-
交叉反应 (详细)
-
Species reactivity (expected):Mouse, Rat and Pig.
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
-
免疫原
- Peptide from the internal region of the protein sequence according to NP_006648.1, NP_996848.1 Genename: FTCD
-
-
-
-
应用备注
-
Peptide ELISA: Antibody Detection Limit: 1/64000. Western blot: 0.01-0.03 μg/mL. Detects a approx. 60 kDa band in Human Liver lysates (calculatedMW of 58.0 kDa according to NP_006648.1 and NP_996848.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- FTCD (Formiminotransferase Cyclodeaminase (FTCD))
-
别名
- 58K Golgi Protein
-
背景
- 58K Golgi protein antibodies are excellent for use as markers for the Golgi complex. The 58K Golgi protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency, also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.Synonyms: FTCD, Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, Golgi Marker 58K, Golgi marker, LCHC1
-
基因ID
- 10841, 9606
-
UniProt
- O95954
抗原
-