KPNA3 抗体 (C-Term)
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Quick Overview for KPNA3 抗体 (C-Term) (ABIN374393)
抗原
See all KPNA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- C-DPTANLQTKE FNF
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特异性
- This antibody detects Importin subunit alpha-3 at C-term.
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交叉反应 （详细）
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Species reactivity (expected):Canine (Dog), Cow.
Species reactivity (tested):Human, Mouse, Rat. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide from C Terminus of the protein sequence according to NP_002258.2 Genename: KPNA3
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anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 1-210) antibody
KPNA3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (C-Term) antibodyVerified KPNA3 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (C-Term) antibodyKPNA3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 1-50) antibodyKPNA3 适用: 人, 小鼠 IHC, IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 3-220) antibodyKPNA3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 422-521) antibodyKPNA3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (C-Term) antibody (Biotin)Verified KPNA3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, IP, ICC 宿主: 山羊 Polyclonal Biotin
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 1-50) antibodyKPNA3 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (N-Term) antibodyKPNA3 适用: 人, 小鼠, 大鼠, 豚鼠, 斑马鱼, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (C-Term) antibodyKPNA3 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.1-0.5 μg/mL. Approx 55-60 kDa band observed in Human Testis and Kidneylysates (predicted size of approx.50 kDa according to NP_002258). Immunohistochemistry: 5-10 μg/mL. In paraffin embedded Human Heart shows strong pixulate staining ofmyocardial fibres in transverse section.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "Inhibition of spinal 5-HT3R reverted diabetes-induced mechanical hypersensitivity in a GABAAR-mediated neurotransmission-dependent manner." in: Neuroscience, Vol. 304, pp. 228-39, (2016) (PubMed).
: "PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis." in: Journal of hepatology, Vol. 59, Issue 1, pp. 105-13, (2013) (PubMed).
: "Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin ?." in: Biochemical and biophysical research communications, Vol. 405, Issue 4, pp. 697-702, (2011) (PubMed).
: "Notch1 signaling is mediated by importins alpha 3, 4, and 7." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 18, pp. 3187-96, (2010) (PubMed).
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- KPNA3 (Karyopherin alpha 3 (Importin alpha 4) (KPNA3))
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别名
- KPNA3 / Importin alpha-3
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背景
- The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that KPNA3 may be involved in the nuclear transport system. The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.Synonyms: Importin alpha Q2, Karyopherin subunit alpha-3, QIP2, SRP1-gamma
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基因ID
- 3839
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NCBI登录号
- NP_002258
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UniProt
- O00505
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途径
- Protein targeting to Nucleus
抗原
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