FOXC1 抗体 (C-Term)
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北京 101111
Quick Overview for FOXC1 抗体 (C-Term) (ABIN374336)
抗原
See all FOXC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- RTSGAFVYDC SKF
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特异性
- This antibody detects FOXC1 / FKHL7 / FREAC3 at C-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Zebrafish.
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纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide from C-Terminus of the protein sequence according to NP_001444.2. Genename: FOXC1
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anti-Forkhead Box C1 (FOXC1) (C-Term) antibody
Verified FOXC1 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) antibodyFOXC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 1-79) antibodyFOXC1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 488-515), (C-Term) antibodyFOXC1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22897 unconjugated
anti-Forkhead Box C1 (FOXC1) (Center) antibodyFOXC1 适用: 人, 小鼠, 大鼠, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 101-200) antibodyFOXC1 适用: 人, 小鼠, 大鼠, 山羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 62-186) antibodyFOXC1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (Internal Region) antibodyVerified FOXC1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 406-455) antibodyFOXC1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 464-553) antibodyFOXC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D11 unconjugated
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应用备注
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Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.5-1.5 μg/mL. Approx 55 kDa band observed in Human Bone Marrow lysates(calculated MW of 56.5 kDa according to NP_001444.1). Immunohistochemistry: 3 μg/mL. In paraffin embedded Human Kidney shows nuclearstaining of some cells in the glomeruli.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.
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: "FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost." in: Investigative ophthalmology & visual science, Vol. 59, Issue 6, pp. 2548-2554, (2019) (PubMed).
: "Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation." in: The Journal of clinical investigation, Vol. 126, Issue 7, pp. 2437-51, (2017) (PubMed).
: "Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients." in: Cell death & disease, Vol. 5, pp. e1069, (2014) (PubMed).
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- FOXC1 (Forkhead Box C1 (FOXC1))
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别名
- FOXC1 / FKHL7 / FREAC3
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背景
- FOXC1 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined, however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.Synonyms: FREAC-3, Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3
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分子量
- 56.8kDa (NP_001444.1).
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基因ID
- 2296
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NCBI登录号
- NP_001444
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UniProt
- Q12948
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途径
- Chromatin Binding, Glycosaminoglycan Metabolic Process
抗原
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