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- 抗原 See all FOXC1 抗体
- FOXC1 (Forkhead Box C1 (FOXC1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FOXC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- FOXC1/2 Antibody detects endogenous levels of total FOXC1/2
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide
- 亚型
- IgG
- Top Product
- Discover our top product FOXC1 Primary Antibody
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anti-Forkhead Box C1 (FOXC1) (C-Term) antibody
Verified FOXC1 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 1-79) antibodyFOXC1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (Center) antibodyFOXC1 适用: 人, 小鼠, 大鼠, 小鸡 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 101-200) antibodyFOXC1 适用: 人, 小鼠, 大鼠, 山羊 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 62-186) antibodyFOXC1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) antibodyFOXC1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (C-Term) antibodyFOXC1 适用: 人, 小鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 464-553) antibodyFOXC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D11 unconjugated
anti-Forkhead Box C1 (FOXC1) (AA 406-455) antibodyFOXC1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C1 (FOXC1) (Internal Region) antibodyVerified FOXC1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB 1:500~1:1000, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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- 抗原
- FOXC1 (Forkhead Box C1 (FOXC1))
- 别名
- FOXC1/2 (FOXC1 产品)
- 别名
- ARA antibody, FKHL7 antibody, FREAC-3 antibody, FREAC3 antibody, IGDA antibody, IHG1 antibody, IRID1 antibody, RIEG3 antibody, FoxC1 antibody, fkhl7 antibody, freac-3 antibody, freac3 antibody, igda antibody, ihg1 antibody, irid1 antibody, rieg3 antibody, xfd-11 antibody, ara antibody, FOXC1 antibody, foxc1 antibody, Fkh1 antibody, Mf1 antibody, Mf4 antibody, ch antibody, fkh-1 antibody, frkhda antibody, CFKH-1 antibody, XFD-11 antibody, foxc1.2 antibody, id:ibd5079 antibody, forkhead box C1 antibody, forkhead box C1 S homeolog antibody, forkhead box C1 L homeolog antibody, Forkhead box protein C1 antibody, winged helix transcription factor XFD-11 antibody, forkhead box C1b antibody, FOXC1 antibody, Foxc1 antibody, foxc1.S antibody, foxc1 antibody, foxc1.L antibody, foxc1-A antibody, foxc1b antibody
- 背景
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Description: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:15299087, PubMed:15684392, PubMed:16492674, PubMed:27907090, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:7957066, PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176). Upon DNA-binding, promotes DNA bending (PubMed:7957066, PubMed:14506133). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963).
Gene: FOXC1
- 分子量
- 57 kDa
- 基因ID
- 2296
- UniProt
- Q12948, Q99958
- 途径
- Chromatin Binding, Glycosaminoglycan Metabolic Process
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