ADAM8 抗体 (C-Term)
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北京 101111
Quick Overview for ADAM8 抗体 (C-Term) (ABIN374195)
抗原
See all ADAM8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- C-QRKQGAGAPT AP
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特异性
- This antibody is expected to recognise isoform 1 and 3 (NP_001100.3 and NP_001157962.1).
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交叉反应 (详细)
- Species reactivity (tested):Human.
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纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide from C Terminus of the protein sequence according to NP_001100.3, NP_001157962.1. Genename: ADAM8
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应用备注
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Peptide ELISA: Limit dilution 1: 1000. Western blot: 1-3 μg/mL. Approx 90 kDa band seen in Human Brain lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))
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别名
- CD156a / ADAM8
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背景
- Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.Synonyms: Cell surface antigen MS2, Disintegrin and metalloproteinase domain-containing protein 8, MS2
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分子量
- 88.8 kDa according to NP_001100.3.
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基因ID
- 101
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NCBI登录号
- NP_001100
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UniProt
- P78325
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途径
- Activation of Innate immune Response, M Phase
抗原
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