DUSP8 抗体 (N-Term)
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Quick Overview for DUSP8 抗体 (N-Term) (ABIN374169)
抗原
See all DUSP8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- *AGDRLPRKVM DAK-C
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特异性
- This antibody detetcs Dual specificity protein phosphatase 8 at N-term.
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纯化方法
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
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免疫原
- Peptide from N Terminus of the protein sequence according to NP_004411.2 Genename: DUSP8
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应用备注
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Peptide ELISA: Limit dilution 1: 4000. Western blot: 1-3 μg/mL. Approx 60-65 kDa bands seen in Human Heart lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
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- DUSP8 (Dual Specificity Phosphatase 8 (DUSP8))
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背景
- DUSP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structur/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.Synonyms: Dual specificity protein phosphatase 8
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基因ID
- 1850
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NCBI登录号
- NP_004411
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UniProt
- Q13202
抗原
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