UCHL1 抗体
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Quick Overview for UCHL1 抗体 (ABIN372739)
抗原
See all UCHL1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Specific for the the ~24 kDa UCHL1 protein.
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交叉反应 （详细）
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Species reactivity (expected):Mamalia.
Species reactivity (tested):Bovine, Human, Mouse and Rat. -
纯化方法
- Ig Fraction
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免疫原
- Recombinant full length human UCHL1 purified from E. coli.
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亚型
- Ig Fraction
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anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 2-223) antibody
UCHL1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 2-223) antibodyUCHL1 适用: 小鼠 WB, IHC, FACS, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 59-223) antibodyUCHL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 2-223) antibodyUCHL1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) antibodyUCHL1 适用: 人, 大鼠 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal rUCHL1-775 unconjugated Recombinant Antibody
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 187-216), (C-Term) antibodyUCHL1 适用: 人, 大鼠, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB7379 unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 1-220) antibodyUCHL1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) antibodyMicroarray verified UCHL1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB215939 unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 1-223) antibodyUCHL1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B8-4D2 unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) antibodyUCHL1 适用: 人, 大鼠, 小鼠, Cow, Pig WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal 31A3 unconjugated
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应用备注
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Western blotting: 1/2,500. Immunofluorescence: 1/500. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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- UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))
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别名
- UCHL1 / PGP9.5
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背景
- Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.Synonyms: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1
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基因ID
- 7345
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NCBI登录号
- NP_004172
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UniProt
- P09936
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途径
- Feeding Behaviour
抗原
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