Peripherin 抗体
Our Local Distributor
北京 101111
Quick Overview for Peripherin 抗体 (ABIN372702)
抗原
See all Peripherin (PRPH) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应 (详细)
-
Species reactivity (expected):many Mammalian.
Species reactivity (tested):Rat. -
纯化方法
- Ig Fraction
-
免疫原
- Recombinant rat peripherin expressed in and purified from E. coli.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
-
Western blot: 1/1000. Immunofluorescence: 1/500. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
-
-
- Peripherin (PRPH)
-
别名
- Peripherin
-
背景
- Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.Synonyms: NEF4, PRPH, PRPH1
-
基因ID
- 10116
-
UniProt
- P21807
抗原
-