IFNAR1 抗体 (pSer535, pSer539)
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Quick Overview for IFNAR1 抗体 (pSer535, pSer539) (ABIN372660)
抗原
See all IFNAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer535, pSer539
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特异性
- This antibody is specific for the IFNAR1 protein phosphorylated at Ser535,539. Note: The Molecular Weight of the IFNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells, the mature form is ~110-130k.
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交叉反应 （详细）
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Species reactivity (expected):Bovine, Canine, Human, Mouse, Sheep and non-Human Primates.
Species reactivity (tested):Rat. -
纯化方法
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
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免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser535,539 of Human IFNAR1.
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亚型
- IgG
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anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 470-557) antibody
IFNAR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 162-188) antibodyIFNAR1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21945 unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (pSer535), (pSer538) antibodyIFNAR1 适用: 人, 大鼠 ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) antibodyIFNAR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) antibodyIFNAR1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (pSer535), (pSer539) antibodyIFNAR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 28-127) antibodyIFNAR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (pSer535), (Ser539) antibodyIFNAR1 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 162-188) antibodyIFNAR1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 351-450) antibodyIFNAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot: 1/1000. Immunohistochemistry: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, (2010) (PubMed).
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: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, (2010) (PubMed).
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- IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
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别名
- IFNAR1
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背景
- Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).Synonyms: CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN-R-1, IFN-alpha Receptor alpha, IFN-alpha/beta receptor 1, Interferon-alpha/beta receptor alpha chain, Type I interferon receptor 1
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基因ID
- 3454
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NCBI登录号
- NP_000620
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UniProt
- P17181
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途径
- JAK/STAT Signaling, Hepatitis C
抗原
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