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IFNAR1 抗体 (pSer535, pSer539)

This anti-IFNAR1 antibody is a 兔 多克隆 antibody detecting IFNAR1 in WB 和 IHC (fro). Suitable for 人, 小鼠, 大鼠, Cow, 犬, Non-Human Primate 和 绵羊. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN372660
发货至: 中国

Quick Overview for IFNAR1 抗体 (pSer535, pSer539) (ABIN372660)

抗原

See all IFNAR1 抗体
IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

适用

人, 小鼠, 大鼠, Cow, 犬, Non-Human Primate, 绵羊

宿主

  • 91
  • 19
  • 1
  • 1

克隆类型

  • 79
  • 30
  • 2
多克隆

标记

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  • 10
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  • 2
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  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This IFNAR1 antibody is un-conjugated

应用范围

  • 48
  • 33
  • 32
  • 27
  • 25
  • 25
  • 10
  • 7
  • 5
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 20
    • 16
    • 13
    • 9
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer535, pSer539

    特异性

    This antibody is specific for the IFNAR1 protein phosphorylated at Ser535,539. Note: The Molecular Weight of the IFNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells, the mature form is ~110-130k.

    交叉反应 (详细)

    Species reactivity (expected):Bovine, Canine, Human, Mouse, Sheep and non-Human Primates.
    Species reactivity (tested):Rat.

    纯化方法

    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

    免疫原

    Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser535,539 of Human IFNAR1.

    亚型

    IgG
  • 应用备注

    Western blot: 1/1000. Immunohistochemistry: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody undiluted (in aliquots) at-20 °C.
  • Bhattacharya, HuangFu, Liu, Veeranki, Baker, Koumenis, Diehl, Fuchs: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, (2010) (PubMed).

  • 抗原

    IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

    别名

    IFNAR1

    背景

    Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).Synonyms: CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN-R-1, IFN-alpha Receptor alpha, IFN-alpha/beta receptor 1, Interferon-alpha/beta receptor alpha chain, Type I interferon receptor 1

    基因ID

    3454

    NCBI登录号

    NP_000620

    UniProt

    P17181

    途径

    JAK/STAT Signaling, Hepatitis C
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