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Glutamate Receptor 1 抗体 (pSer845)

Name: Glutamate Receptor 1 抗体 (pSer845)
SKU: ABIN372653
Availability: OutOfStock

GLUR1 适用: 人, 大鼠, 小鼠, Non-Human Primate WB, IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Image no. 1 for anti-Glutamate Receptor 1 (GLUR1) (pSer845) antibody (ABIN372653) (Glutamate Receptor 1 抗体 (pSer845))

1 image

(9 references)

产品编号 ABIN372653

发货至: 中国

Datasheet as PDF

抗原 See all Glutamate Receptor 1 (GLUR1) 抗体

Glutamate Receptor 1 (GLUR1)
抗原表位
17

15

15

13

13

13

12

6

5

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
pSer845
适用
105

105

90

10

6

4

4

4

3

2

2

2

1
人, 大鼠, 小鼠, Non-Human Primate
宿主
115

24

1
兔
Compatible Secondaries
克隆类型
107

33
多克隆
标记
65

8

6

6

6

6

6

6

5

5

3

3

3

3

3

1

1

1

1

1

1
This Glutamate Receptor 1 antibody is un-conjugated
应用范围
93

40

40

38

36

25

15

15

12

4

4

2

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

特异性

Specific for the ~100k GluR1 protein phosphorylated at Ser845 in Western blots of rat brain extracts. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is s completely eliminated by treatment with lambda-Ptase.

交叉反应（详细）

Species reactivity (expected):Human, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

纯化方法

Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

免疫原

Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser845 of GluR1.

亚型

IgG

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anti-Glutamate Receptor 1 (GLUR1) (AA 19-300) antibody
GLUR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor 1 (GLUR1) (pSer845) antibody
GLUR1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor 1 (GLUR1) (AA 19-360) antibody
GLUR1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor 1 (GLUR1) (C-Term) antibody
GLUR1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor 1 (GLUR1) antibody
Microarray verified GLUR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB177574 unconjugated

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 unconjugated

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (HRP)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 HRP

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (FITC)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 FITC

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (Biotin)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 Biotin

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (PE)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 PE

应用备注

Western blot: 1/1000. Immunofluorescence. Immunohistochemitsry on Frozen Sections: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
状态

Liquid

缓冲液

10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C/-80 °C

储存方法

Store the antibody undiluted (in aliquots) at-20 °C or (in aliquots) at -80 °C for long term.
Shen, Fu, Cheng, Fu, Ip: "Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 2, pp. 464-72, (2013) (PubMed).

Santini, Feyder, Gangarossa, Bateup, Greengard, Fisone et al.: "Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in ..." in: The Journal of biological chemistry, Vol. 287, Issue 33, pp. 27806-12, (2012) (PubMed).

Sears, Liu, Narayanan, Sharf, Yeckel, Laubach, Aghajanian, DiLeone: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).

Rebholz, Nishi, Liebscher, Nairn, Flajolet, Greengard: "CK2 negatively regulates Galphas signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 33, pp. 14096-101, (2009) (PubMed).

Santini, Heiman, Greengard, Valjent, Fisone: "Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia." in: Science signaling, Vol. 2, Issue 80, pp. ra36, (2009) (PubMed).

Zheng, Keifer: "PKA has a critical role in synaptic delivery of GluR1- and GluR4-containing AMPARs during initial stages of acquisition of in vitro classical conditioning." in: Journal of neurophysiology, Vol. 101, Issue 5, pp. 2539-49, (2009) (PubMed).

Meyer, Richer, Benkovic, Hayashi, Kansy, Hale, Moy, Kim, OCallaghan, Tsai, Greengard, Nairn, Cowan, Miller, Antich, Bibb: "Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18561-6, (2008) (PubMed).

Nishi, Kuroiwa, Miller, OCallaghan, Bateup, Shuto, Sotogaku, Fukuda, Heintz, Greengard, Snyder: "Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 42, pp. 10460-71, (2008) (PubMed).

Davies, Goebel-Goody, Coultrap, Browning: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).
抗原

Glutamate Receptor 1 (GLUR1)

别名

Glutamate Receptor 1 / GLUR1 (GLUR1 产品)

别名

GLUH1 antibody, GLUR1 antibody, GLURA antibody, GluA1 antibody, HBGR1 antibody, gluR-A antibody, 2900051M01Rik antibody, Glr-1 antibody, Glr1 antibody, GluR-A antibody, GluRA antibody, Glur-1 antibody, Glur1 antibody, HIPA1 antibody, gluR-K1 antibody, GRIA1 antibody, glur1 antibody, Gria1 antibody, glur1b antibody, gria1.2 antibody, sb:eu293 antibody, ZfGluR1a antibody, glur1a antibody, gria1.1 antibody, zfGRIA1[a] antibody, glutamate ionotropic receptor AMPA type subunit 1 antibody, glutamate receptor, ionotropic, AMPA1 (alpha 1) antibody, glutamate receptor, ionotropic, AMPA 1 antibody, glutamate receptor, ionotropic, AMPA 1 L homeolog antibody, GluR1 protein antibody, Glutamate receptor 1 antibody, glutamate receptor, ionotropic, AMPA 1b antibody, glutamate receptor, ionotropic, AMPA 1a antibody, GRIA1 antibody, Gria1 antibody, gria1 antibody, gria1.L antibody, glur1 antibody, glr-1 antibody, gria1b antibody, gria1a antibody

背景

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II (McGlade-McCulloh et al., 1993, Mammen et al., 1999, Roche et al., 1996). In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory (Soderling and Derkach, 2000).Synonyms: AMPA-selective glutamate receptor 1, AMPA1, GLUH1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic

基因ID

50592

NCBI登录号

NP_113796

UniProt

P19490

途径

PI3K-Akt Signaling