Glutamate Receptor 1 抗体 (pSer831)
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北京 101111
Quick Overview for Glutamate Receptor 1 抗体 (pSer831) (ABIN372652)
抗原
See all Glutamate Receptor 1 (GLUR1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer831
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特异性
- Specific for the ~100k GluR1 protein phosphorylated at Ser831. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is completely eliminated by lambda-phosphatase treatment.
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交叉反应 （详细）
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Species reactivity (expected):Human, Canine, Chicken and Mouse.
Species reactivity (tested):Rat. -
纯化方法
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
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免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser831 of GluR1.
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亚型
- IgG
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anti-Glutamate Receptor 1 (GLUR1) (AA 19-300) antibody
GLUR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) (AA 19-360) antibodyGLUR1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) (C-Term) antibodyGLUR1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) antibodyMicroarray verified GLUR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB177574 unconjugated
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibodyGLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 unconjugated
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (HRP)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 HRP
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (FITC)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 FITC
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (Biotin)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 Biotin
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (PE)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 PE
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (APC)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 APC
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应用备注
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Western blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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: "Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B." in: Molecular pharmacology, Vol. 84, Issue 6, pp. 834-43, (2013) (PubMed).
: "Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24806-18, (2011) (PubMed).
: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).
: "CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17930-7, (2010) (PubMed).
: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).
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: "Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B." in: Molecular pharmacology, Vol. 84, Issue 6, pp. 834-43, (2013) (PubMed).
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- Glutamate Receptor 1 (GLUR1)
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别名
- Glutamate Receptor 1 / GLUR1
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背景
- The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II (McGlade-McCulloh et al., 1993, Mammen et al., 1999, Roche et al., 1996). In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory (Soderling and Derkach, 2000).Synonyms: AMPA-selective glutamate receptor 1, AMPA1, GLUH1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic
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基因ID
- 50592
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NCBI登录号
- NP_113796
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UniProt
- P19490
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途径
- PI3K-Akt Signaling
抗原
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