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TOLLIP 抗体

TOLLIP 适用: 人 WB, EIA, FACS 宿主: 小鼠 Monoclonal SB40a unconjugated
产品编号 ABIN371662
发货至: 中国
  • 抗原 See all TOLLIP 抗体
    TOLLIP (Toll Interacting Protein (TOLLIP))
    适用
    • 42
    • 30
    • 21
    • 17
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 47
    • 11
    • 2
    小鼠
    克隆类型
    • 50
    • 11
    单克隆
    标记
    • 36
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TOLLIP antibody is un-conjugated
    应用范围
    • 33
    • 18
    • 13
    • 13
    • 13
    • 9
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)
    特异性
    This antibody is specific to Human Tollip. Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins.
    产品特性
    Synonyms: Toll-interacting protein
    纯化方法
    Purified
    免疫原
    Recombinant Tollip.
    克隆位点
    SB40a
    亚型
    IgG2a
    Top Product
    Discover our top product TOLLIP Primary Antibody
  • 应用备注
    ELISA. Western Blot. Flow Cytometry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    TOLLIP (Toll Interacting Protein (TOLLIP))
    别名
    TOLLIP (TOLLIP 产品)
    背景
    Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP.Synonyms: Toll-interacting protein
    基因ID
    54472
    UniProt
    Q9H0E2
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