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CD51 抗体

ITGAV 适用: 人 FACS, IHC (fro) 宿主: 小鼠 Monoclonal 13C2 unconjugated
产品编号 ABIN371554
发货至: 中国
  • 抗原 See all CD51 (ITGAV) 抗体
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    适用
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    宿主
    • 65
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    小鼠
    克隆类型
    • 57
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    单克隆
    标记
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    This CD51 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    产品特性
    Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha
    纯化方法
    Purified
    克隆位点
    13C2
    亚型
    IgG1
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  • 应用备注
    Flow Cytometry: < / = 1 μg/10^6 cells. Immunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    别名
    CD51 / ITGAV (ITGAV 产品)
    背景
    Integrin alpha V chain interacts with the integrin beta 3 subunit/CD61 to form the alpha-V-beta-3 heterodimer/vitronectin receptor. It is expressed on endothelial cells, some activated leukocytes, NK cells, macrophages, neutrophils, and platelets. Integrin alpha V also forms heterodimers with the integrin beta 1, beta 5, beta 6, and beta 8 subunits. Alpha-V-beta-3 is an activation dependent receptor for platelet attachment and spreading on vitronectin and other matrix components. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus By similarity. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31. (Ref.1-4)Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha
    UniProt
    P06756
    途径
    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex
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