LAMP1 抗体
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北京 101111
Quick Overview for LAMP1 抗体 (ABIN371199)
抗原
See all LAMP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody is specific to CD107a/LAMP-1 (Mr 110-140 kDa with a core protein of Mr ~40 kDa).
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交叉反应 (详细)
- Species reactivity (tested):Mouse
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产品特性
- Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
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纯化方法
- Purified
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免疫原
- Plasma membrane fraction of mouse embryo NIH3T3 cell line. (Ref. 1)
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亚型
- IgG2a
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应用备注
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Flow cytometry: < / = 1 μg/10^6 cells. (Ref.5)Immunohistochemistry on Frozen Sections. (Ref.5)Immunoaffinity Chromatography. (Ref.2)Western blot. (Ref.5)Immunoprecipitation. (Ref.1,3)Immunoelectron Microscopy. (Ref.6)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
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别名
- CD107a / LAMP1
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背景
- CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. (Ref.1) It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. (Ref.2) CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and Beige mutant mice. (Ref.3) LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. (Ref.4)Synonyms: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1
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基因ID
- 16783
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UniProt
- P11438
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途径
- Autophagy
抗原
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