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FLT3 抗体 (AA 589-593)

Name: FLT3 抗体 (AA 589-593)
SKU: ABIN362818
Availability: OutOfStock

FLT3 适用: 人 IF 宿主: 兔 Polyclonal unconjugated

(2 references)

产品编号 ABIN362818

发货至: 中国

Datasheet as PDF

抗原 See all FLT3 抗体

FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
抗原表位
20

18

18

15

12

12

9

8

7

7

7

5

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 589-593
适用
157

53

7

4

2

1

1

1

1

1
人
宿主
159

14

2

1
兔
Compatible Secondaries
克隆类型
160

16
多克隆
标记
69

13

11

9

7

7

7

7

7

7

7

5

4

4

4

4

4
This FLT3 antibody is un-conjugated
应用范围
126

69

54

54

31

26

19

14

8

8

4

3

2

1

1
Immunofluorescence (IF)

特异性

The antibody detects endogenous level of total FLT3 protein.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

免疫原

Peptide sequence around AA 589-593 (Y-F-Y-V-D) derived from Human FLT3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

亚型

IgG

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anti-Fms-Related tyrosine Kinase 3 (FLT3) (C-Term) antibody
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FLT3 适用: 人 FACS 宿主: 小鼠 Monoclonal BV10A4 FITC

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FLT3 适用: 人 FACS 宿主: 小鼠 Monoclonal BV10A4 PE

anti-Fms-Related tyrosine Kinase 3 (FLT3) (AA 650-750) antibody
FLT3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Ninagawa, Murakami, Isobe, Tanaka, Nakagawa, Torihashi: "Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits." in: Differentiation; research in biological diversity, Vol. 82, Issue 3, pp. 153-64, (2011) (PubMed).

Meads, Nouwen: "Does emotional disclosure have any effects? A systematic review of the literature with meta-analyses." in: International journal of technology assessment in health care, Vol. 21, Issue 2, pp. 153-64, (2005) (PubMed).
抗原

FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

别名

FLT3 (FLT3 产品)

别名

FLT3 antibody, B230315G04 antibody, CD135 antibody, Flk-2 antibody, Flk2 antibody, Flt-3 antibody, Ly72 antibody, wmfl antibody, FLK-2 antibody, FLK2 antibody, STK1 antibody, fms related tyrosine kinase 3 antibody, FMS-like tyrosine kinase 3 antibody, fms-related tyrosine kinase 3 antibody, FLT3 antibody, Flt3 antibody

背景

FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

分子量

160 kDa

NCBI登录号

NP_004110

UniProt

P36888

途径

RTK signaling