HDAC5 抗体 (pSer498)
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北京 101111
Quick Overview for HDAC5 抗体 (pSer498) (ABIN362218)
抗原
See all HDAC5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer498
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特异性
- The antibody detects endogenous level of HDAC5 only when phosphorylated at serine498.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
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免疫原
- Peptide sequence around phosphorylation site of pSer498 (T-Q-S (p) -S-P) derived from Human HDAC5, 7. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
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亚型
- IgG
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anti-Histone Deacetylase 5 (HDAC5) (pSer498) antibody
HDAC5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) (C-Term) antibodyHDAC5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) (AA 13-1107) antibodyHDAC5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) (AA 330-429) antibodyHDAC5 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G2 unconjugated
anti-Histone Deacetylase 5 (HDAC5) antibodyHDAC5 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) antibodyHDAC5 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) (pSer259) antibodyHDAC5 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) (AA 102-197) antibodyHDAC5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) (C-Term) antibodyHDAC5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 5 (HDAC5) (C-Term) antibodyHDAC5 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." in: Blood, Vol. 115, Issue 14, pp. 2971-9, (2010) (PubMed).
: "Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts." in: Development (Cambridge, England), Vol. 137, Issue 7, pp. 1075-84, (2010) (PubMed).
: "Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila." in: Development (Cambridge, England), Vol. 137, Issue 1, pp. 5-13, (2009) (PubMed).
: "Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure." in: Circulation research, Vol. 102, Issue 6, pp. 695-702, (2008) (PubMed).
: "GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 5, pp. 892-8, (2008) (PubMed).
: "Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by ..." in: Molecular and cellular biology, Vol. 27, Issue 11, pp. 4105-20, (2007) (PubMed).
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- HDAC5 (Histone Deacetylase 5 (HDAC5))
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别名
- HDAC5
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背景
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. Doppler H, et al. (2005) J Biol Chem. 280(15):15013-15019. McKinsey TA, et al. (2000) Nature. 408(6808): 106-111. Published Papers J Bossuyt, K Helmstadter, X Wu, et al. Ca2+/Calmodulin-Dependent Protein Kinase II {delta} and Protein Kinase D Overexpression Reinforce. Circulation Research, 102(6):695-702.(2008) Pang J, Yan C, Natarajan K, et al. GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5):892-8. (2008) S Lim, M Luo, M Koh, et al. Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin beta-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone.
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分子量
- 124 kDa
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NCBI登录号
- NP_001015
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UniProt
- Q9UQL6
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process
抗原
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