GRP78 抗体
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北京 101111
Quick Overview for GRP78 抗体 (ABIN361825)
抗原
See all GRP78 (HSPA5) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Detects ~78 kDa.
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交叉反应
- Cow, 犬, Fusarium, Hamster, 人, 猴, 小鼠, 兔, 大鼠, 非洲爪蟾
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纯化方法
- Peptide Affinity Purified
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免疫原
- Rat GRP78 (Bip) synthetic peptide conjugated to KLH
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anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) (AA 550-650) antibody
HSPA5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) (Internal Region) antibodyHSPA5 适用: 人, 大鼠, 小鼠 WB, ICC, IF, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) (AA 251-360) antibodyHSPA5 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody (HRP)HSPA5 适用: 大鼠 WB, IHC, ICC, IF, IP 宿主: 兔 Polyclonal HRP
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody (FITC)HSPA5 适用: 大鼠 WB, IHC, ICC, IF, IP 宿主: 兔 Polyclonal FITC
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody (Biotin)HSPA5 适用: 大鼠 WB, IHC, ICC, IF, IP 宿主: 兔 Polyclonal Biotin
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody (PE)HSPA5 适用: 大鼠 WB, IHC, ICC, IF, IP 宿主: 兔 Polyclonal PE
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody (APC)HSPA5 适用: 大鼠 WB, IHC, ICC, IF, IP 宿主: 兔 Polyclonal APC
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody (PerCP)HSPA5 适用: 大鼠 WB, IHC, ICC, IF, IP 宿主: 兔 Polyclonal PerCP
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody (Atto 594)HSPA5 适用: 大鼠 WB, IHC, ICC, IF, IP 宿主: 兔 Polyclonal Atto 594
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应用备注
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
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说明
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A 1:1000 dilution of ABIN361824 was sufficient for detection of Grp78 in 10 μg of rat tissue lysate by ECL immunoblot analysis.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C
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: "Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis." in: PLoS ONE, Vol. 8, Issue 1, pp. e54239, (2013) (PubMed).
: "Activation of the unfolded protein response during anoxia exposure in the turtle Trachemys scripta elegans." in: Molecular and cellular biochemistry, Vol. 374, Issue 1-2, pp. 91-103, (2013) (PubMed).
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: "Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis." in: PLoS ONE, Vol. 8, Issue 1, pp. e54239, (2013) (PubMed).
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- GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
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别名
- GRP78
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背景
- GRP78 is a ubiquitously expressed, 78- kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
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基因ID
- 25617
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NCBI登录号
- NP_037215
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UniProt
- P06761
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途径
- Thyroid Hormone Synthesis, ER-Nucleus Signaling
抗原
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