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SNCA 抗体 (pSer129)

SNCA 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN361526
发货至: 中国
  • 抗原 See all SNCA 抗体
    SNCA (Synuclein, alpha (SNCA))
    抗原表位
    • 53
    • 30
    • 17
    • 14
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    • 11
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    • 5
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    • 2
    • 2
    • 2
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    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    pSer129
    适用
    • 262
    • 170
    • 154
    • 14
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    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
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    大鼠
    宿主
    • 199
    • 88
    • 5
    • 3
    • 1
    • 1
    克隆类型
    • 188
    • 110
    多克隆
    标记
    • 144
    • 22
    • 19
    • 13
    • 9
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    • 8
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    • 5
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    • 2
    • 2
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    This SNCA antibody is un-conjugated
    应用范围
    • 224
    • 161
    • 110
    • 74
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    • 52
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    • 12
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    • 2
    • 2
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    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    特异性
    Specific for the ~15 kDa alpha-synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    bovine, canine, non-human primate
    纯化方法
    Antigen Affinity Purified from Pooled Serum
    免疫原
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser129 conjugated to KLH
    Top Product
    Discover our top product SNCA Primary Antibody
  • 应用备注
    Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    储存条件
    -20 °C
  • 抗原
    SNCA (Synuclein, alpha (SNCA))
    别名
    SNCA (SNCA 产品)
    背景
    Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson?s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005, Masliah et al., 2005). Anti-Phospho-Ser129 Alpha Synuclein Western blot of rat cortex lysate showing specific labeling of the ~15 k alpha synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). .
    分子量
    '15 kDa
    基因ID
    29219
    UniProt
    P37377
    途径
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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