IFNAR1 抗体 (pSer535, pSer539)
(2 references)Quick Overview for IFNAR1 抗体 (pSer535, pSer539) (ABIN361505)
抗原
See all IFNAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer535, pSer539
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特异性
- Specific for IFNAR1 protein phosphorylated at Ser535,539.
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交叉反应
- 人
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预测反应
- bovine, canine, mouse, non-human primate, rat, sheep
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纯化方法
- Antigen Affinity Purified from Pooled Serum
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免疫原
- Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 conjugated to KLH
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anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 470-557) antibody
IFNAR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 28-290) antibodyIFNAR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 162-188) antibodyIFNAR1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21945 unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (pSer535), (pSer538) antibodyIFNAR1 适用: 人, 大鼠 ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 300-350) antibodyIFNAR1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (pSer535), (pSer539) antibodyIFNAR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 28-127) antibodyIFNAR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (pSer535), (Ser539) antibodyIFNAR1 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) antibodyIFNAR1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Interferon alpha/beta Receptor 1 (IFNAR1) (AA 162-188) antibodyIFNAR1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended Dilution: WB: 1:1000 IHC: 1:1000 Quality Control: Western blots performed on each lot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
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储存条件
- -20 °C
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: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, (2010) (PubMed).
: "Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46614-20, (2004) (PubMed).
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: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, (2010) (PubMed).
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- IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
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别名
- IFNAR1
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背景
- Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-a Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003). Anti-Phospho Ser535,539 IFNAR1 Western blot of immunoprecipitates from HEK 293 cells transfected with 1. Mock, 2. IFNAR1 WT, and 3. IFNAR1 S535A and S539A mutants showing specific immunolabeling of the ~110k to ~130k IFNAR1 WT. The immunolabeling is absent in IFNAR1 Ser535 and Ser539 mutants (Control). The immunolabeling is blocked by the phosphopeptide (Phos) used as the antigen but not by the corresponding dephosphopeptide (Dephos).
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分子量
- 110-130 kDa
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基因ID
- 3654
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UniProt
- P17181
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途径
- JAK/STAT Signaling, Hepatitis C
抗原
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