Glutamate Receptor 1 抗体 (pSer831)
Quick Overview for Glutamate Receptor 1 抗体 (pSer831) (ABIN361476)
抗原
See all Glutamate Receptor 1 (GLUR1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer831
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特异性
- Specific for endogenous levels of the ~100 kDa GluR1 protein phosphorylated at Ser831. Immunolabeling is completely eliminated by treatment with λ-phosphatase.
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交叉反应
- 人, 小鼠, 大鼠
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交叉反应 (详细)
- The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with canine, chicken, human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
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预测反应
- canine, chicken, human
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产品特性
- Our GluR1-Subunit (Ser831) rabbit polyclonal phosphospecific primary antibody is produced in-house. It detects GluR1-Subunit (Ser831) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB.
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纯化方法
- Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
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免疫原
- Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser831 of rat GluR1 conjugated to keyhole limpet hemocyanin (KLH).
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亚型
- IgG
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应用备注
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Dilution Range: WB Brain: 1:1000
Dilution Range: WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
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注意事项
- Avoid repeated freezing and thawing
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储存条件
- -20 °C
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储存方法
- Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
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有效期
- 12 months
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: "Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain." in: Brain and behavior, Vol. 10, Issue 3, pp. e01543, (2020) (PubMed).
: "Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine." in: Neuropharmacology, (2016) (PubMed).
: "Differential CaMKII regulation by voltage-gated calcium channels in the striatum." in: Molecular and cellular neurosciences, Vol. 68, pp. 234-43, (2016) (PubMed).
: "Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine." in: Journal of neurochemistry, Vol. 133, Issue 6, pp. 795-805, (2015) (PubMed).
: "Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice." in: European journal of pharmacology, Vol. 738, pp. 237-44, (2014) (PubMed).
: "Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration." in: Neurochemistry international, Vol. 64, pp. 48-54, (2013) (PubMed).
: "Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens." in: Neuroscience letters, Vol. 490, Issue 3, pp. 180-4, (2011) (PubMed).
: "Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24806-18, (2011) (PubMed).
: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).
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: "Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain." in: Brain and behavior, Vol. 10, Issue 3, pp. e01543, (2020) (PubMed).
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- Glutamate Receptor 1 (GLUR1)
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别名
- GRIA1
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背景
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Synonyms: GLUR 1 antibody, GLUR A antibody, AMPA 1 antibody, AMPA selective glutamate receptor 1 antibody, AMPA-selective glutamate receptor 1 antibody, GluA1 antibody, GLUH1 antibody, GluR K1 antibody, GluR-1 antibody, GluR-A antibody, GluR-K1 antibody, GLUR1 antibody, GLURA antibody, GluRK1 antibody, Glutamate receptor 1 antibody, Glutamate receptor ionotropic AMPA 1 antibody, Glutamate receptor ionotropic antibody, Glutamate receptor, ionotropic, AMPA 1 antibody, Gria1 antibody, GRIA1_HUMAN antibody, HBGR1 antibody, MGC133252 antibody, OTTHUMP00000160643 antibody, OTTHUMP00000165781 antibody, THUMP00000224241 antibody, OTTHUMP00000224242 antibody, OTTHUMP00000224243 antibody
Description Logic: Our GluR1-Subunit (Ser831) rabbit polyclonal phosphospecific primary antibody is produced . It detects GluR1-Subunit (Ser831) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB.
Gene Name Alternatives: GRIA1
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分子量
- 100 kDa
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基因ID
- 50592
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NCBI登录号
- NP_113796
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UniProt
- P19490
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途径
- PI3K-Akt Signaling
抗原
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