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PLK1 抗体 (pThr210)

PLK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN361457
发货至: 中国
  • 抗原 See all PLK1 抗体
    PLK1 (Polo-Like Kinase 1 (PLK1))
    抗原表位
    • 18
    • 17
    • 15
    • 12
    • 8
    • 7
    • 5
    • 3
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    • 2
    • 2
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    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    pThr210
    适用
    • 124
    • 48
    • 43
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    宿主
    • 103
    • 20
    • 2
    • 1
    克隆类型
    • 105
    • 21
    多克隆
    标记
    • 75
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
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    • 1
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    This PLK1 antibody is un-conjugated
    应用范围
    • 101
    • 47
    • 31
    • 28
    • 27
    • 19
    • 18
    • 15
    • 7
    • 5
    • 4
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    Western Blotting (WB)
    特异性
    Specific for ~66k PLK phosphorylated at Thr210. Immunolabeling of the PLK band is completely blocked by (-phosphatase treatment.
    交叉反应
    人, 大鼠
    预测反应
    bovine, canine, mouse, non-human primate, Xenopus, Zebrafish
    纯化方法
    Antigen Affinity Purified from Pooled Serum
    免疫原
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr210 conjugated to KLH
    Top Product
    Discover our top product PLK1 Primary Antibody
  • 应用备注
    Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    储存条件
    -20 °C
  • 抗原
    PLK1 (Polo-Like Kinase 1 (PLK1))
    别名
    PLK1 (PLK1 产品)
    别名
    PLK antibody, STPK13 antibody, plk antibody, PLK-1 antibody, Plx1 antibody, stpk13 antibody, Plk antibody, cb525 antibody, cb636 antibody, ik:tdsubc_2d1 antibody, wu:fb37g11 antibody, wu:fb76g03 antibody, xx:tdsubc_2d1 antibody, polo like kinase 1 antibody, polo like kinase 1 S homeolog antibody, polo-like kinase 1 antibody, polo-like kinase 1 (Drosophila) antibody, Serine/threonine-protein kinase plk-1 antibody, PLK1 antibody, plk1.S antibody, plk1 antibody, Plk1 antibody, plk-1 antibody
    背景
    Polo-like kinases are important regulators of cell cycle progression. PLK1 is a highly conserved Ser/Thr kinase that has essential roles in the formation of mitotic bipolar spindles (van Vugt et al., 2004). Deregulated expression of PLK?s is detected in many types of cancer and associated with oncogenesis (Takei et al., 2005). It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210 (van de Weerdt et al., 2005). Anti-Phospho-Thr210 PLK1 Western blot of rat synaptic membrane showing specific immunolabeling of the ~66 k PLK protein phosphorylated at Thr210 (control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the phospho-Thr210 PLK antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.
    分子量
    '66 kDa
    基因ID
    5347
    UniProt
    P53350
    途径
    Cell Division Cycle, M Phase
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