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MAPT 抗体 (pSer416)

Name: MAPT 抗体 (pSer416)
Brand: antibodies-online
SKU: ABIN361456
Availability: OutOfStock

MAPT 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated

Western blots of rat brain homogenate showing specific immunolabeling of the ~59, 65, 68k Tau isoforms phosphorylated at Ser416(control). (MAPT 抗体 (pSer416))

Western blot of rat brain homogenate showing specific immunolabeling of the ~59 kDa, ~65 kDa, ~68 kDa Tau isoforms phosphorylated at Ser416 in the first lane (-). (MAPT 抗体 (pSer416))

2 images

(1 reference)

产品编号 ABIN361456

发货至: 中国

Datasheet as PDF

抗原 See all MAPT 抗体

MAPT (Microtubule-Associated Protein tau (MAPT))
抗原表位
10

9

8

8

7

6

6

6

6

6

5

5

5

5

5

5

4

4

4

4

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
pSer416
适用
211

110

99

14

12

8

7

6

4

3

2

2

2

1

1

1
大鼠
宿主
197

17

6
兔
Compatible Secondaries
克隆类型
194

26
多克隆
标记
174

17

6

5

2

2

2

2

2

2

2

2

1

1
This MAPT antibody is un-conjugated
应用范围
190

119

61

34

22

20

12

3

2

2

2

1

1
Western Blotting (WB)

特异性

Specific for ~59, 65, 68k tau protein phosphorylated at Ser416.

交叉反应

小鼠, 大鼠

预测反应

bovine, canine, human, non-human primate

纯化方法

Antigen Affinity Purified from Pooled Serum

免疫原

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser416 conjugated to KLH

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MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pSer235) antibody
MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pSer262) antibody
MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (AA 1-100) antibody
MAPT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pThr205) antibody
MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pThr181) antibody
MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pSer404) antibody
MAPT 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pSer404) antibody
MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pSer396) antibody
MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein tau (MAPT) (pSer422) antibody
MAPT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

限制

仅限研究用
状态

Liquid

缓冲液

100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

储存条件

-20 °C
Wang, Hall, Lee, Kamgar-Parsi, Bi, Baudry: "The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation." in: Scientific reports, Vol. 7, Issue 1, pp. 11771, (2019) (PubMed).
抗原

MAPT (Microtubule-Associated Protein tau (MAPT))

别名

MAPT (MAPT 产品)

别名

DDPAC antibody, FTDP-17 antibody, MAPTL antibody, MSTD antibody, MTBT1 antibody, MTBT2 antibody, PPND antibody, TAU antibody, AI413597 antibody, AW045860 antibody, Mtapt antibody, Tau antibody, RNPTAU antibody, pTau antibody, tau antibody, xtp antibody, MAPT antibody, PHF-tau antibody, slc6a6 antibody, taut antibody, wu:fc26e12 antibody, microtubule associated protein tau antibody, microtubule-associated protein tau antibody, microtubule associated protein tau S homeolog antibody, Microtubule-associated protein tau antibody, solute carrier family 6 (neurotransmitter transporter), member 6b antibody, MAPT antibody, Mapt antibody, mapt.S antibody, LOC5580230 antibody, CpipJ_CPIJ013260 antibody, tau antibody, slc6a6b antibody

背景

Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990). Anti-Phospho-Ser416 Tau Western blot of rat brain homogenate showing specific immunolabeling of the ~59, 65, 68k Tau isoforms phosphorylated at Ser416(control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

分子量

59/65/68 kDa

基因ID

69329

UniProt

P19332

途径

MAPK Pathway, Microtubule Dynamics, M Phase, Regulation of Cell Size