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GRIN2C 抗体 (N-Term)

Name: GRIN2C 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN361398
Availability: OutOfStock

This anti-GRIN2C antibody is a 兔多克隆 antibody detecting GRIN2C in WB 和 IP. Suitable for 大鼠. This Primary Antibody has been cited in 1 publication.

Western blots of 10 ug of rat cerebellar lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor. (GRIN2C 抗体 (N-Term))

Western blot of 10 µg of rat cerebellar lysate showing specific immunolabeling of the ~140 kDa NR2C subunit of the NMDA receptor. (GRIN2C 抗体 (N-Term))

2 images

(1 reference)

产品编号 ABIN361398

发货至: 中国

Datasheet as PDF

Quick Overview for GRIN2C 抗体 (N-Term) (ABIN361398)

抗原

See all GRIN2C 抗体

GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This GRIN2C antibody is un-conjugated

应用范围

Western Blotting (WB), Immunoprecipitation (IP)

抗原表位
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N-Term

特异性

Specific for the ~140k NR2C subunit of the NMDA receptor. Also labels the ~180k NR2A and the ~180k NR2B subunits of the NMDA receptor. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody.

交叉反应

人, 小鼠, 大鼠

纯化方法

Antigen Affinity Purified from Pooled Serum

免疫原

Fusion protein from the N-terminal region of the NR2C subunit
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 908-1007) antibody
GRIN2C 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) antibody
GRIN2C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 69-118) antibody
GRIN2C 适用: 人, 小鼠, 大鼠, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 1-171) antibody
GRIN2C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (Internal Region) antibody
GRIN2C 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 365-377), (Extracellular) antibody
GRIN2C 适用: 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (pSer1244) antibody
GRIN2C 适用: 人, 小鼠, 大鼠, Cow, 犬, 灵长类 WB 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 1-171) antibody
GRIN2C 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (pSer1096) antibody
GRIN2C 适用: 人, 小鼠, 大鼠, Cow, 犬, 灵长类 WB 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (N-Term) antibody
GRIN2C 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended Dilution: WB: 1:1000 IHC, IF (frozen sections, unpublished observations): 1:1000 to 1:2000 IP: 3 µl per 200 µg lysate Quality Control: Western blots performed on each lot.

限制

仅限研究用
状态

Lyophilized

缓冲液

Lyophilized

储存条件

-20 °C
Wang, Imamura, Ishibashi, Chandana, Yamamoto, Noda: "The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice." in: Journal of neurochemistry, (2010) (PubMed).
抗原

GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

别名

GRIN2C

背景

The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Anti-NMDA Receptor, NR2C Subunit Western blot of 10 ug of rat cerebellar lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor.

分子量

'140 kDa

基因ID

24411

UniProt

Q00961

途径

Synaptic Membrane