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- 抗原 See all Vimentin (VIM) 抗体
- Vimentin (VIM)
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适用
- 人
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宿主
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小鸡
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克隆类型
- 多克隆
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标记
- This Vimentin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- Specific for the ~50kDa Vimentin protein. It is expected that it will work on other mammalian tissues.
- 交叉反应
- 牛, 人, 小鼠, 大鼠
- 纯化方法
- Total IgY fraction
- 免疫原
- Recombinant human vimentin purified from E. coli
- Top Product
- Discover our top product VIM Primary Antibody
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- 应用备注
- Recommended Dilution: WB: 1:1,000 IF: 1:500 Quality Control: Western blots performed on each lot.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- total IgY fraction in PBS + 10 mM Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib." in: Carcinogenesis, Vol. 33, Issue 9, pp. 1639-46, (2012) (PubMed).
: "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 5031-42, (2012) (PubMed).
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Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib." in: Carcinogenesis, Vol. 33, Issue 9, pp. 1639-46, (2012) (PubMed).
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- 抗原
- Vimentin (VIM)
- 别名
- VIM (VIM 产品)
- 背景
- Vimentin is the major protein subunit of the 10nm or intermediate filaments (IFs) found in many kinds of mesenchymal and epithelial cells as well as developing neuronal and astrocytic precursor cells in the CNS. Vimentin is thought to be critically involved in lymphocyte adhesion and transmigration (Nieminen M et al. 2006). Copolymers are frequently formed between vimentin and other IFs, such as GFAP (in many kinds of astrocytes), desmin (in muscle cells) and neurofilament proteins (in developing neurons). Antibodies to vimentin are useful in studies of stem cells and generally to reveal the filamentous cytoskeleton. Recent studies suggest that vimentin affects prostate cancer cells motility and invasiveness (Zhao et al. 2008).
- 分子量
- '50 kDa
- 基因ID
- 7431
- UniProt
- P08670
- 途径
- Caspase Cascade in Apoptosis
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