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Peripherin 抗体

This anti-Peripherin antibody is a 小鼠 单克隆 antibody detecting Peripherin in WB 和 IF. Suitable for 大鼠.
产品编号 ABIN361363
发货至: 中国

Quick Overview for Peripherin 抗体 (ABIN361363)

抗原

See all Peripherin (PRPH) 抗体
Peripherin (PRPH)

适用

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大鼠

宿主

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小鼠

克隆类型

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单克隆

标记

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This Peripherin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF)

克隆位点

7C5
  • 特异性

    Specific for the ~57kDa peripherin protein. This antibody performs well on aldehyde fixed tissues.

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    most mammalian

    纯化方法

    Protein G purified culture supernatant

    免疫原

    Recombinant rat peripherin expressed in and purified from E. coli

    亚型

    IgG1
  • 应用备注

    Recommended Dilution: WB:1:1,000 IF: 1:200 Quality Control: Western blots performed on each lot.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    total IgG fraction + 10 mM Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • 抗原

    Peripherin (PRPH)

    别名

    PRPH

    背景

    Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. Anti-Peripherin Western blot of rat cerebellar lysate showing specific immunolabeling of the ~ 57k peripherin protein.

    分子量

    '57 kDa

    基因ID

    3414

    UniProt

    P21807
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