NEFH 抗体
Quick Overview for NEFH 抗体 (ABIN361351)
抗原
See all NEFH 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Specific for the ~200k Neurofilament H protein.
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交叉反应
- 小鸡, 哺乳动物
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纯化方法
- Total IgY fraction
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免疫原
- Purified bovine NF-H
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应用备注
- Recommended Dilution: WB: 1:50,000 IF: 1:25,000 Quality Control: Western blots performed on each lot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- total IgY fraction in PBS + 10 mM Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system." in: Cellular and molecular life sciences : CMLS, Vol. 79, Issue 7, pp. 371, (2022) (PubMed).
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: "SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system." in: Cellular and molecular life sciences : CMLS, Vol. 79, Issue 7, pp. 371, (2022) (PubMed).
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- NEFH (Neurofilament, Heavy Polypeptide (NEFH))
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别名
- NEFH
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背景
- Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H (1). NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) (2) and Alzheimer's disease (3). Anti-Neurofilament H Left: Western blot of rat cortex lysate showing specific immunolableing of the ~200k NF-H protein. Right: Immunofluorescence of rat cortical neurons and glia showing NF-H staining (red).
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分子量
- '200 kDa
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基因ID
- 4744
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UniProt
- P12036
抗原
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