Podoplanin 抗体
Quick Overview for Podoplanin 抗体 (ABIN360956)
抗原
See all Podoplanin (PDPN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognizes Rat Podoplanin.
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纯化方法
- Protein G Chromatography
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免疫原
- BALB/c mice using a membrane protein fraction of isolated Rat glomeruli
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anti-Podoplanin (PDPN) (AA 91-166) antibody
PDPN 适用: 小鼠, 大鼠 WB, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Podoplanin (PDPN) (AA 23-143) antibodyPDPN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Podoplanin (PDPN) (AA 24-126) antibodyPDPN 适用: 人 ELISA, IF, IHC (f), Coat 宿主: 小鼠 Monoclonal PDPN-1433 unconjugated
anti-Podoplanin (PDPN) antibodyPDPN 适用: 小鼠 WB, FACS, IP, IHC (p) 宿主: 大鼠 Monoclonal 8F11 unconjugated
anti-Podoplanin (PDPN) antibodyPDPN 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Podoplanin (PDPN) (AA 1-206) antibodyPDPN 适用: 人 ELISA, FACS, IF, ICC 宿主: 小鼠 Monoclonal 5E2 unconjugated
anti-Podoplanin (PDPN) antibodyPDPN 适用: 小鼠 WB, IP, IHC (fro) 宿主: Golden Syrian Hamster Monoclonal 811 unconjugated
anti-Podoplanin (PDPN) (AA 1-100) antibodyPDPN 适用: Synthetic ELISA, IF, IHC (f), Coat 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
anti-Podoplanin (PDPN) (N-Term) antibodyPDPN 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Podoplanin (PDPN) (AA 97-146) antibodyPDPN 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS, pH 6.0 without preservatives and stabilizers
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for two weeks or (in aliquots) at -20 °C for longer.
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- Podoplanin (PDPN)
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别名
- Podoplanin
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背景
- Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1-alpha (T1A), and aggrus, is a 36 kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid precursor. It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 207-228) and a short cytoplasmic tail (aa 229-238). The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47 % aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of Podoplanin. Through its association with CLEC-2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.Synonyms: Aggrus, GP36, Glycoprotein 36, PA2.26 antigen, PDPN, PSEC0003, PSEC0025, T1-alpha
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基因ID
- 54320
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NCBI登录号
- NP_062231
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UniProt
- Q64294
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途径
- Dicarboxylic Acid Transport
抗原
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