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RAGE 抗体 (Extracellular Domain)

This anti-RAGE antibody is a 大鼠 单克隆 antibody detecting RAGE in WB, IF 和 IHC (fro). Suitable for 小鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN360934
发货至: 中国

Quick Overview for RAGE 抗体 (Extracellular Domain) (ABIN360934)

抗原

See all RAGE (AGER) 抗体
RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This RAGE antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

克隆位点

2B65
  • 抗原表位

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    Extracellular Domain

    特异性

    This antibody detects RAGE.

    纯化方法

    Protein A/G Affinity Chromatography

    免疫原

    Mouse Recombinant RAGE extracellular domain. Remarks: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized rat).

    亚型

    IgG2
  • 应用备注

    Western Blot: 1/500-1/1000. Immunohistochemistry on Frozen Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 溶解方式

    Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

    浓度

    0,5 mg/mL

    缓冲液

    PBS without preservatives

    储存液

    Without preservative

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Aue, Englert, Harrer, Schwiering, Gaab, König, Adams, Schmidtko, Friebe, Groneberg: "NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis." in: Respiratory research, Vol. 24, Issue 1, pp. 167, (2023) (PubMed).

  • 抗原

    RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

    别名

    RAGE / AGER

    背景

    The Receptor for Advanced Glycation Endproducts (RAGE) is a member of the Immunoglobin superfamily of cell surface markers. This protein is able to interact with many molecules including: advanced glycation endproducts (AGE), amphoterin, and ligands. Research has shown that the accumulation of RAGE ligands in the biological system (endothelium mononuclear phagocytes, neurons and smooth muscle cells) can lead to destructive tissue diseases such as diabetic retinopathy, amyloidoses, tumors and inflammation disorders. RAGE is expressed by endothelium mononuclear phagocytes, smooth muscle and neurons.Synonyms: Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

    基因ID

    10090

    UniProt

    Q62151

    途径

    Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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