Angiopoietin 4 抗体
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Quick Overview for Angiopoietin 4 抗体 (ABIN360871)
抗原
See all Angiopoietin 4 (ANGPT4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects Mouse Angiopoietin-3 in Western blotting. Other species not tested.
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纯化方法
- Protein A/G affinity chromatography
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免疫原
- Recombinant Angiopoietin-3
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亚型
- IgG2
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anti-Angiopoietin 4 (ANGPT4) (AA 410-503) antibody
ANGPT4 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) antibodyANGPT4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) (AA 25-111) antibodyANGPT4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B7 unconjugated
anti-Angiopoietin 4 (ANGPT4) (N-Term) antibodyANGPT4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) (AA 19-52), (N-Term) antibodyANGPT4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) (AA 32-144) antibodyANGPT4 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) (AA 25-111) antibodyANGPT4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) (N-Term) antibodyANGPT4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) (AA 25-144) antibodyANGPT4 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 4 (ANGPT4) (AA 35-84) antibodyANGPT4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.
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缓冲液
- 0.2 μm filtered PBS solution
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Angiopoietin 4 (ANGPT4)
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别名
- Angiopoietin-4
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背景
- Mouse Angiopoietin3 (ANG3), is a secreted glycoprotein belonging to the angiopoietin family. It has the characteristic structural motifs of angiopoietins including the coiled coiled domain near the amino-terminus and a fibrinogen like domain at the C-terminus. Mouse ANG 3 cDNA encodes a 509 amino acid (aa) precursor protein with a 21 aa signal peptide. It shares 47 % , 46 % and 54 % aa sequence identity with mouse ANG1, mouse ANG2 and human ANG4, respectively. Although the sequence homology is much higher between the human and mouse counterparts for ANG1 (97 %) and ANG2 (85 %), mouse ANG3 is believed to be an ortholog of human ANG4 based on chromosomal localization studies. Human ANG4 is highly expressed in lung and in cultured human umbilical vein endothelial cells (HUVECs). In contrast, mouse ANG3 is expressed in multiple mouse tissues. Human ANG4 is an agonist that can bind and activate Tie2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Mouse ANG3 has been reported to be a Tie2 antagonist. It is likely that mouse ANG3, like ANG2, may exert agonist or antagonist activities depending on the cell context.Synonyms: ANG-3, ANG-4, ANG3, ANG4, ANGPT4
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基因ID
- 11602
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NCBI登录号
- NP_033771
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UniProt
- Q9WVH6
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途径
- RTK signaling
抗原
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