WISP2 抗体 (Middle Region)
Our Local Distributor
北京 101111
Quick Overview for WISP2 抗体 (Middle Region) (ABIN358746)
抗原
See all WISP2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Middle Region
-
特异性
- This antibody reacts to WISP2.
-
纯化方法
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
-
免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human WISP2.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
-
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.25 mg/mL
-
缓冲液
- PBS with 0.09 % (W/V) sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
-
-
- WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))
-
别名
- WISP2
-
背景
- Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.Synonyms: CCN5, CT58, CTGF-L, CTGFL, Connective tissue growth factor-like protein, Connective tissue growth factor-related protein 58, UNQ228/PRO261, WISP-2, WNT1-inducible-signaling pathway protein 2
-
基因ID
- 8839
-
NCBI登录号
- NP_003872
-
UniProt
- O76076
-
途径
- WNT signaling, Growth Factor Binding
抗原
-