PROX1 抗体 (Center)
(2 references)Quick Overview for PROX1 抗体 (Center) (ABIN357418)
抗原
See all PROX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody detects PROX1 at Center.
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纯化方法
- Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Then the antibody is purified by peptide affinity purification.
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免疫原
- KLH conjugated synthetic peptide selected from the Center region of human PROX1
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亚型
- Ig Fraction
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anti-Prospero Homeobox 1 (PROX1) (AA 638-737) antibody
PROX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H6 unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 492-522) antibodyPROX1 适用: 人, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 492-520) antibodyPROX1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 185-214) antibodyPROX1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 638-737) antibodyPROX1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E7 unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 444-478) antibodyPROX1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51404 unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 1-300) antibodyPROX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 547-737) antibodyPROX1 适用: 人, 马, Avian WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) antibodyPROX1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 492-520) antibodyPROX1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB15208 unconjugated
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应用备注
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ELISA: 1/1,000. Western blot: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
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: "Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis." in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Vol. 20, Issue 1, pp. 104-115, (2017) (PubMed).
: "Impact of prospero homeobox-1 on tumor cell behavior and prognosis in colorectal cancer." in: American journal of cancer research, Vol. 5, Issue 11, pp. 3286-300, (2016) (PubMed).
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: "Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis." in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Vol. 20, Issue 1, pp. 104-115, (2017) (PubMed).
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- PROX1 (Prospero Homeobox 1 (PROX1))
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别名
- PROX-1
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背景
- The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.Synonyms: Homeobox prospero-like protein PROX1, PROX1, Prospero homeobox protein 1
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分子量
- 83162 Da
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基因ID
- 5629, 9606
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UniProt
- Q92786
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途径
- Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
抗原
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