DKK4 抗体 (N-Term)
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Quick Overview for DKK4 抗体 (N-Term) (ABIN357073)
抗原
See all DKK4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 7-36, N-Term
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序列
- DKK4
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特异性
- This antibody detects DKK4 at N-term.
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纯化方法
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
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免疫原
- KLH conjugated synthetic peptide between 7~36 amino acids from the N-terminal region of Human DKK4
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亚型
- Ig Fraction
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anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (AA 19-224) antibody
DKK4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (AA 107-212) antibodyDKK4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (AA 19-224) antibodyDKK4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (C-Term) antibodyVerified DKK4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (AA 1-224) antibodyDKK4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (AA 1-224) antibodyDKK4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (AA 37-141) antibodyDKK4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (AA 188-217), (C-Term) antibodyDKK4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
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别名
- Dickkopf-4 (DKK4)
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背景
- DKK4, like DKK1, DKK2, and DKK3, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis detected no expression of DKK4, but RT-PCR analysis detected DKK4 expression in cerebellum, T-cell, esophagus, and lung cDNA libraries. DKK4 blocks Xenopus Wnt8, Wnt3a, and Wnt2b, but not Dsh or Fz8, induction of a secondary axis in frog embryos, indicating that DKKs antagonize WNT function upstream of WNT receptors.Synonyms: Dickkopf-related protein 4, Dkk-4
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分子量
- 24875 Da
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基因ID
- 27121, 9606
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UniProt
- Q9UBT3
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途径
- WNT signaling
抗原
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