HDAC10 抗体 (N-Term)
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北京 101111
Quick Overview for HDAC10 抗体 (N-Term) (ABIN356657)
抗原
See all HDAC10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody is specific to HDAC10 (N-term).
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纯化方法
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from a region of human HDAC10 within AA's 1-100.
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亚型
- Ig Fraction
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anti-Histone Deacetylase 10 (HDAC10) (AA 207-412) antibody
HDAC10 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) (AA 18-219) antibodyHDAC10 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3B6B8 unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyHDAC10 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyKD Validated HDAC10 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB6050 unconjugated Recombinant Antibody
anti-Histone Deacetylase 10 (HDAC10) (AA 16-46), (N-Term) antibodyHDAC10 适用: 人 WB 宿主: 兔 Polyclonal RB2583 unconjugated
anti-Histone Deacetylase 10 (HDAC10) (N-Term) antibodyHDAC10 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyHDAC10 适用: 人 WB, IHC, FACS, IP 宿主: 小鼠 Monoclonal 4D4 unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyHDAC10 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 2H6 unconjugated
anti-Histone Deacetylase 10 (HDAC10) (AA 561-669) antibodyHDAC10 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) (N-Term) antibodyHDAC10 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/1,000. Western blot: 1/50-1/100.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- HDAC10 (Histone Deacetylase 10 (HDAC10))
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别名
- HDAC10
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背景
- Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (2). Eight members of HDAC family have been identified in the past several years (3,4). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93 % identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (4). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. HDAC8 interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate to convert RUNX1 into a constitutive transcriptional repressor.Synonyms: HD10, Histone deacetylase 10
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基因ID
- 83933, 9606
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UniProt
- Q969S8
抗原
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