NGFR 抗体
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- 抗原 See all NGFR 抗体
- NGFR (Nerve Growth Factor Receptor (NGFR))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NGFR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Purification (Purif)
- 原理
- Mouse monoclonal antibody to p75NTR (ME20.4)
- 特异性
- Specific for p75NTR.
- 交叉反应
- Cat, 犬, 人, Marmoset, Pig, 兔
- 纯化方法
- Affinity purified
- 免疫原
- Human melanoma cell lines
- 亚型
- IgG1, IgG1 kappa
- Top Product
- Discover our top product NGFR Primary Antibody
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- 应用备注
- IHC WB FC. A concentration of 2-10 μg,ml is recommended. The optimal working concentration should be determined by the end user. This antibody may also be used for immunoabsorptive purification of NGF-receptors. See also the eLab Book at the end of this page.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in 150 μL of sterile water. Centrifuge to remove any insoluble material.
- 注意事项
- Avoid freeze and thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- 有效期
- 12 months
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- 抗原
- NGFR (Nerve Growth Factor Receptor (NGFR))
- 别名
- p75NTR (NGFR 产品)
- 背景
- FUNCTION: Low affinity receptor which can bind to NGF BDNF NT-3 and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2 TRAF4 TRAF6 PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein.
- UniProt
- P08138
- 途径
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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