Histone H4 抗体 (ciArg3, N-Term)
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Quick Overview for Histone H4 抗体 (ciArg3, N-Term) (ABIN347794)
抗原
See all Histone H4 (HISTH4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- ciArg3, N-Term
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特异性
- Reacts with human Histone H4 Citrulline at the position 3 (10 kDa)
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交叉反应 (详细)
- No cross reaction with free H4 nor with other citrullinated proteins. May cross reacts with other species due to sequence homology.
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纯化方法
- Antiserum
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免疫原
- Synthetic peptide derived from Nter region of Human Histone H4, containing Citrulline at position 3
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亚型
- IgG
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA(1:5000 - 1:10000) IHC(1:100 - 1:1000) WB(1:100 - 1:1000) -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Must be reconstituted in distilled water.
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储存条件
- 4 °C/-20 °C
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储存方法
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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有效期
- 24 months
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- Histone H4 (HISTH4)
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别名
- Histone H4
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背景
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
抗原
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