The antibody UBN1-02 recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band.
交叉反应 (详细)
Human, Other species Not tested
纯化方法
Purified by protein-A affinity chromatography.
纯度
> 95 % (by SDS-PAGE)
免疫原
Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1.
Western blotting: Recommended dilution: 1-5 μg/mL, positive control: HeLa cell line.
限制
仅限研究用
浓度
1 mg/mL
缓冲液
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Do not freeze.
储存条件
4 °C
储存方法
Store at 2-8°C. Do not freeze.
抗原
Ubinuclein 1 (UBN1)
别名
UBN1
背景
Ubinuclein 1,Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.,Ubinuclein 1, VT4