ORAI3 抗体 (N-Term)
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北京 101111
Quick Overview for ORAI3 抗体 (N-Term) (ABIN337113)
抗原
See all ORAI3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- Recognizes human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kD multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. AHP1496 is not expected to cross react with either ORAI1 or ORAI2.
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纯化方法
- Affinity purified
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免疫原
- A 15 amino acid peptide from near the amino terminus of human ORAI3.
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anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) antibody
ORAI3 适用: 人 WB 宿主: 兔 Monoclonal 25GB4720 unconjugated Recombinant Antibody
anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (C-Term) antibodyORAI3 适用: 人, 大鼠 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 2H2G9 unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (N-Term) antibodyORAI3 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (C-Term) antibodyORAI3 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (C-Term) antibodyORAI3 适用: 人, 小鼠 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3) (AA 1-30) antibodyORAI3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Approved: IHC, IHC-P (5 μg/mL), WB
Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 5 μg/mL. Western Blot: LS-B2385 detects a band of approximately 35kD in A20 cell lysates. -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing. Store undiluted.
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储存条件
- 4 °C,-20 °C
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储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles. Store undiluted.
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- ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
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别名
- ORAI3
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背景
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Name/Gene ID: ORAI3
Synonyms: ORAI3, Protein orai-3, TMEM142C, Transmembrane protein 142C -
基因ID
- 93129
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UniProt
- Q9BRQ5
抗原
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