CD176 抗体
CD176
适用: 人
IHC, IHC (p)
宿主: 小鼠
Monoclonal
Tn218
unconjugated
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- 抗原 See all CD176 products
- CD176 (Thomsen Friedenreich Antigen (CD176))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD176 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Alpha GalNacOSer/Thr. Molecular Weight: several HM weight glycoproteins.
- 免疫原
- Asialo ovine submaxillary mucin (AOSM)
- 克隆位点
- Tn218
- 亚型
- IgM
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anti-Thomsen Friedenreich Antigen (CD176) antibody
CD176 适用: 人, 小鼠, 大鼠 IHC, IF, StM 宿主: 小鼠 Monoclonal A78-G-A7 unconjugated
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- 应用备注
- IHC, ICC (frozen or formalin–fixed paraffin-embedded (FFPE) tissue sections, cell smears) Dilute conc. antibodies 1:50-1:100 using streptavidin-Biotin system or polymer system for 30 minutes at RT. Prediluted antibody is used directly without dilution. The optimum dilution should be determined by the individual lab. Positive Control: Human gastrointestinal tumor. Cellular Localization: Cytoplasmic and epithelial membrane.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- The antibodies are supplied as concentrated cell culture medium in PBS with 0.05% azide, pH 7.4. The Prediluted antibody is supplied in our Universal antibody dilution buffer (AR-6526) green in color.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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- 抗原
- CD176 (Thomsen Friedenreich Antigen (CD176))
- 别名
- Thomsen Friedenreich Antigen (CD176 产品)
- 背景
- Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator. This antibody stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach, breast.
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