CD176 抗体
This 小鼠 单克隆 antibody specifically detects CD176 in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7882458
发货至:
中国
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Contact Info
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北京 101111
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Quick Overview for CD176 抗体 (ABIN7882458)
抗原
CD176
(Thomsen Friedenreich Antigen (CD176))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This CD176 antibody is un-conjugated
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
质量等级
Carrier-free
克隆位点
A84-A-F10
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原理
- Thomsen-Friedenreich Antigen Antibody / CD176 (azide and preservative free)
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纯化方法
- PEG precipitation
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免疫原
- Neuraminidase-treated human red blood cells were used as the immunogen for this Thomsen-Friedenreich Antigen antibody.
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亚型
- IgM, kappa
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anti-Thomsen Friedenreich Antigen (CD176) antibody
CD176 适用: 人, 小鼠, 大鼠 IF 宿主: 小鼠 Monoclonal A78-G-A7 unconjugated
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应用备注
- Optimal dilution of the Thomsen-Friedenreich Antigen antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Thomsen-Friedenreich Antigen antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- CD176 (Thomsen Friedenreich Antigen (CD176))
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别名
- Thomsen-Friedenreich Antigen
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背景
- Recognizes a disaccharide epitope, Gal 1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF , including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The TF antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. Considered to be a pan-carcinoma marker. It is capable to agglutinate desialylated red blood cells. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. It is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. TF antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. Its presence on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.
抗原
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