CD176 抗体
The 小鼠 单克隆 anti-CD176 antibody is suitable to detect CD176 in samples from 人. It has been validated for IHC 和 IHC (p).
产品编号 ABIN336905
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for CD176 抗体 (ABIN336905)
抗原
CD176
(Thomsen Friedenreich Antigen (CD176))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This CD176 antibody is un-conjugated
应用范围
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
克隆位点
Tn218
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特异性
- Alpha GalNacOSer/Thr. Molecular Weight: several HM weight glycoproteins.
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免疫原
- Asialo ovine submaxillary mucin (AOSM)
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亚型
- IgM
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anti-Thomsen Friedenreich Antigen (CD176) antibody
CD176 适用: 人, 小鼠, 大鼠 IF 宿主: 小鼠 Monoclonal A78-G-A7 unconjugated
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应用备注
- IHC, ICC (frozen or formalin–fixed paraffin-embedded (FFPE) tissue sections, cell smears) Dilute conc. antibodies 1:50-1:100 using streptavidin-Biotin system or polymer system for 30 minutes at RT. Prediluted antibody is used directly without dilution. The optimum dilution should be determined by the individual lab. Positive Control: Human gastrointestinal tumor. Cellular Localization: Cytoplasmic and epithelial membrane.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The antibodies are supplied as concentrated cell culture medium in PBS with 0.05% azide, pH 7.4. The Prediluted antibody is supplied in our Universal antibody dilution buffer (AR-6526) green in color.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- CD176 (Thomsen Friedenreich Antigen (CD176))
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别名
- Thomsen Friedenreich Antigen
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背景
- Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator. This antibody stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach, breast.
抗原
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