8-OHDG 抗体
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北京 101111
Quick Overview for 8-OHDG 抗体 (ABIN335419)
抗原
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- 8-OHDG in all species. No observable crossreactivity for the following analogues: guanosine (G), 7methylG, 6SHG, 8bromoG, dA, dC, dT, dI, dU, dG, O6methyldG, 8OHdA, guanine (Gua), O6methylGua, 8OHGua, uric acid, Urea, creatine, creatinine Slight but minimal (<1 %) crossreactivity for the following analogues: 8sulfhydrylG and 8OHG 1
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纯化方法
- Prepared as ascites then ammonium sulphate purified
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免疫原
- 8-OHdG-conjugated Keyhole Limpet Hemocyanin
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亚型
- IgG1 kappa
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anti-8-Hydroxyguanosine (8-OHDG) antibody
8-OHDG ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG ELISA, IHC, IP, FACS, FM 宿主: 小鼠 Monoclonal 15A3 unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG IHC (p), EIA, IHC (fro) 宿主: 小鼠 Monoclonal 15A3 unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG ELISA, IHC, WB 宿主: 小鼠 Monoclonal 15A3 unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG IHC (p), EIA, IF 宿主: 小鼠 Monoclonal N45-1 unconjugated
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应用备注
- Tested for IHC and ELISA. User should determine optimum titer for each application.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized as 100 ug/mL IgG in10 mM Phosphate buffered saline, pH7.4 containing 1.0 % BSA.
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储存条件
- -20 °C
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: "Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury." in: Scientific reports, Vol. 9, Issue 1, pp. 7995, (2019) (PubMed).
: "OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos." in: Cell death & disease, Vol. 9, Issue 6, pp. 628, (2019) (PubMed).
: "Echinacoside Alleviates UVB Irradiation-Mediated Skin Damage via Inhibition of Oxidative Stress, DNA Damage, and Apoptosis." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 6851464, (2018) (PubMed).
: "Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress." in: Cell death & disease, Vol. 8, Issue 8, pp. e2972, (2018) (PubMed).
: "Effects of lipopolysaccharide on the response of C57BL/6J mice to whole thorax irradiation." in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 105, Issue 3, pp. 341-9, (2013) (PubMed).
: "Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits." in: Biological & pharmaceutical bulletin, Vol. 35, Issue 4, pp. 494-502, (2012) (PubMed).
: "Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats." in: Journal of biomedicine & biotechnology, Vol. 2012, pp. 915380, (2012) (PubMed).
: "Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis." in: Journal of clinical biochemistry and nutrition, Vol. 49, Issue 2, pp. 121-4, (2011) (PubMed).
: "Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in acetaminophen-induced liver injury in rats." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 73, Issue 9, pp. 1185-90, (2011) (PubMed).
: "Genistein can mitigate the effect of radiation on rat lung tissue." in: Radiation research, Vol. 173, Issue 5, pp. 602-11, (2010) (PubMed).
: "Hypoxia inducible factor 1alpha signaling in fractionated radiation-induced lung injury: role of oxidative stress and tissue hypoxia." in: Radiation research, Vol. 173, Issue 2, pp. 165-74, (2010) (PubMed).
: "Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 74, Issue 6, pp. 1183-90, (2010) (PubMed).
: "Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion." in: Journal of clinical biochemistry and nutrition, Vol. 47, Issue 2, pp. 130-7, (2010) (PubMed).
: "Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice." in: Malaria journal, Vol. 9, pp. 101, (2010) (PubMed).
: "Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat." in: PLoS ONE, Vol. 5, Issue 9, pp. e12606, (2010) (PubMed).
: "Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease." in: Free radical biology & medicine, Vol. 46, Issue 4, pp. 492-501, (2009) (PubMed).
: "Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 2, pp. 424-32, (2009) (PubMed).
: "Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue." in: International journal of molecular medicine, Vol. 24, Issue 1, pp. 17-22, (2009) (PubMed).
: "Arsenic inhibits in vitro spermatogenesis and induces germ cell apoptosis in Japanese eel (Anguilla japonica)." in: Reproduction (Cambridge, England), Vol. 138, Issue 2, pp. 279-87, (2009) (PubMed).
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: "Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury." in: Aging, Vol. 11, Issue 15, pp. 5548-5569, (2020) (PubMed).
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- 8-OHDG (8-Hydroxyguanosine (8-OHDG))
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别名
- 8 Hydroxyguanosine (8-OHDG)
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物质类
- Chemical
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背景
- 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a product of oxidatively damaged DNA formed by hydroxy radical, singlet oxygen and direct photodynamic action. Anti 8-OHdG monoclonal antibody (clone N45.1) is highly specific for 8-OHdG, and is suitable for immunohistochemistry. Cross reactivity have been checked for 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G).
抗原
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