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Lamin B1 抗体

This anti-Lamin B1 antibody is a 小鼠 单克隆 antibody detecting Lamin B1 in WB, ICC 和 FACS. Suitable for 人, 小鼠, 大鼠, Cow, 兔, 犬, 绵羊 和 斑马鱼. This Primary Antibody has been cited in 9+ publications.
产品编号 ABIN335391
发货至: 中国

Quick Overview for Lamin B1 抗体 (ABIN335391)

抗原

See all Lamin B1 (LMNB1) 抗体
Lamin B1 (LMNB1)

适用

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人, 小鼠, 大鼠, Cow, 兔, 犬, 绵羊, 斑马鱼

宿主

  • 55
  • 34
  • 1
小鼠

克隆类型

  • 53
  • 37
单克隆

标记

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  • 2
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This Lamin B1 antibody is un-conjugated

应用范围

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  • 2
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Western Blotting (WB), Immunocytochemistry (ICC), Flow Cytometry (FACS)

克隆位点

119D5-F1
  • 特异性

    Human, rat, mouse, bovine, rabbit, dog, sheep.

    纯化方法

    Purified

    免疫原

    119D5-F1 is a mouse monoclonal IgG1/kappa antibody derived by fusion of P3/X63.Ag8.653 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with purified rat liver lamins.

    亚型

    IgG1
  • 应用备注

    119D5-F1 reacts with an epitope located C-terminal of residue 231 in lamin B1. 119D5-F1 is suitable for immunocytochemistry, immunoblotting, ELISA and flow cytometry. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for flow cytometry, and for immunocytochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.

    限制

    仅限研究用
  • 储存条件

    4 °C
  • Broers, Ramaekers, Bonne, Yaou, Hutchison: "Nuclear lamins: laminopathies and their role in premature ageing." in: Physiological reviews, Vol. 86, Issue 3, pp. 967-1008, (2006) (PubMed).

    Broers, Bronnenberg, Kuijpers, Schutte, Hutchison, Ramaekers: "Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosis." in: European journal of cell biology, Vol. 81, Issue 12, pp. 677-91, (2003) (PubMed).

    Neri, Raymond, Giordano, Capitani, Martelli: "Lamin A is part of the internal nucleoskeleton of human erythroleukemia cells." in: Journal of cellular physiology, Vol. 178, Issue 3, pp. 284-95, (1999) (PubMed).

    Pugh, Coates, Lane, Raymond, Quinlan: "Distinct nuclear assembly pathways for lamins A and C lead to their increase during quiescence in Swiss 3T3 cells." in: Journal of cell science, Vol. 110 ( Pt 19), pp. 2483-93, (1997) (PubMed).

    Broers, Machiels, Kuijpers, Smedts, van den Kieboom, Raymond, Ramaekers: "A- and B-type lamins are differentially expressed in normal human tissues." in: Histochemistry and cell biology, Vol. 107, Issue 6, pp. 505-17, (1997) (PubMed).

    Jansen, Machiels, Hopman, Broers, Bot, Arends, Ramaekers, Schouten: "Comparison of A and B-type lamin expression in reactive lymph nodes and nodular sclerosing Hodgkin's disease." in: Histopathology, Vol. 31, Issue 4, pp. 304-12, (1997) (PubMed).

    Machiels, Ramaekers, Kuijpers, Groenewoud, Oosterhuis, Looijenga: "Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults." in: The Journal of pathology, Vol. 182, Issue 2, pp. 197-204, (1997) (PubMed).

    Machiels, Broers, Raymond, de Ley, Kuijpers, Caberg, Ramaekers: "Abnormal A-type lamin organization in a human lung carcinoma cell line." in: European journal of cell biology, Vol. 67, Issue 4, pp. 328-35, (1996) (PubMed).

    Weaver, Carson, Walker, Chaly, Lach, Raymond, Brown, Sikorska: "Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes." in: Journal of cell science, Vol. 109 ( Pt 1), pp. 45-56, (1996) (PubMed).

  • 抗原

    Lamin B1 (LMNB1)

    别名

    Lamin B1

    背景

    Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2.

    途径

    Apoptosis, Caspase Cascade in Apoptosis
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