Desmin 抗体
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北京 101111
Quick Overview for Desmin 抗体 (ABIN335365)
抗原
See all Desmin (DES) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Human.
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纯化方法
- Purified
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免疫原
- D9 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with desmin isolated from human leiomyoma.
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亚型
- IgG1
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anti-Desmin (DES) (C-Term) antibody
Verified DES 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Desmin (DES) (AA 1-304) antibodyDES 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) (AA 261-360) antibodyDES 适用: 人, 大鼠, 小鼠, 小鸡 WB, ELISA, IHC (p), FACS, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) antibodyKD Validated DES 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB3120 unconjugated Recombinant Antibody
anti-Desmin (DES) antibodyDES 适用: 人 WB, IF, IHC (p), ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) (AA 121-470) antibodyDES 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) antibodyDES 适用: 人, 大鼠, 小鼠, 小鸡, Hamster, 犬, Pig, 兔, 斑马鱼 WB, IHC, IHC (fro) 宿主: 小鼠 Monoclonal RD301 unconjugated
anti-Desmin (DES) antibodyDES 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal 3E1G4 unconjugated
anti-Desmin (DES) (C-Term) antibodyDES 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) (AA 361-470) antibodyDES 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D12 unconjugated
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应用备注
- D9 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma. D9 is suitable for immunoblotting and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:25 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
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限制
- 仅限研究用
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储存条件
- 4 °C
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: "Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 5, pp. 639-50, (2009) (PubMed).
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- Desmin (DES)
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别名
- Desmin
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背景
- Desmin (53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
抗原
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