XPA 抗体 (full length)
(2 references)Quick Overview for XPA 抗体 (full length) (ABIN3200998)
抗原
See all XPA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- full length
-
交叉反应
- 小鼠
-
交叉反应 （详细）
- Expected to react also with mouse XPA from the sequence homology.
-
纯化方法
- Purified
-
过滤
- Sterile filtered
-
免疫原
- Recombinant full-length human XPA protein
-
亚型
- IgG2b
-
-
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (Center) antibody
XPA 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (Internal Region) antibodyXPA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 211-260) antibodyXPA 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 221-250), (C-Term) antibodyXPA 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB23644 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 185-213), (C-Term) antibodyXPA 适用: 人 WB 宿主: 兔 Polyclonal RB33699 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term) antibodyXPA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term) antibodyXPA 适用: 人, 小鼠, 大鼠, 犬, Cow, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
1. Western blotting: 0. 1~1 g/mL
2. ELISA
3. Inhibition of in vitro excision repair reaction
4. Inhibition of XPA interaction with ERCC1 and TFIIH
Other applications have not been tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.2, 50 % glycerol
-
储存液
- Azide free
-
储存条件
- -20 °C/-80 °C
-
储存方法
- -20 C (For long term storage: -70 C)
-
-
-
: "Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH." in: Biochemical and biophysical research communications, Vol. 321, Issue 4, pp. 815-22, (2004) (PubMed).
: "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain." in: Nature, Vol. 348, Issue 6296, pp. 73-6, (1990) (PubMed).
-
: "Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH." in: Biochemical and biophysical research communications, Vol. 321, Issue 4, pp. 815-22, (2004) (PubMed).
-
- XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))
-
别名
- XPA
-
背景
- XP (Xeroderma pigmentosum) is an autosomal recessive human disease characterized by hypersensitivity to sunlight and a high incidence of skin cancer on sun-exposed skin. Cells from XP patients are hypersensitive to killing by UV irradiation because of a defect in nucleotide excision repair (NER). XP is classified into seven complementation groups (A~G) and a variant form. XPA shows the most severe symptoms. Products encoded by the XP genes function in repairing UV-induced cyclobutane pyrimidine dimmer and (6-4) photoproducts as well as chemically induced variety of DNA lesions. XPA protein consists of 273 amino acids and forms a complex with many proteins such as RPA, ERCC1, TFIIH,XAB1, and XAB2, which plays a role in early step of NER. The hybridoma 5F12 was constructed by Prof. K. Tanaka's group who first cloned the XPA gene.
-
UniProt
- P23025
-
途径
- DNA Damage Repair
抗原
-
