ABL1/2 抗体 (pTyr393, pTyr439)
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- 抗原 See all ABL1/2 (ABL1/ABL2) 抗体
- ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))
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抗原表位
- pTyr393, pTyr439
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ABL1/2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Affinity Chromatography
- 免疫原
- Synthetic phosphopeptide derived from human ABL1/2 around the phosphorylation site of Tyrosine 393/439 (D-T-Yp-T-A).
- Top Product
- Discover our top product ABL1/ABL2 Primary Antibody
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anti-Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2) (pTyr393), (pTyr439) antibody
ABL1/ABL2 适用: 人 IHC, WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2) (Lys5) antibodyABL1/ABL2 适用: 人, 小鼠 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2) (C-Term), (pTyr393), (pTyr439) antibodyABL1/ABL2 适用: 人, 小鼠, 大鼠 IHC, WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2) (Lys5) antibodyABL1/ABL2 适用: 人, 小鼠 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2) (Tyr393), (Tyr429) antibodyABL1/ABL2 适用: 人, 小鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody (in aliquots) at-20 °C.
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- 抗原
- ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))
- 别名
- ABL1 / ABL2 (ABL1/ABL2 产品)
- 背景
- ABL1, an Abl type protein kinase, is associated with cell differentiation, cell division, cell adhesion and stress response. Kinase activity of nuclear ABL1 is mediated by retinoblastoma protein. Additionally, ABL1 has been shown to bind nuclear DNA, and this binding activity is regulated by CDC2-mediated phosphorylation. ABL1 (-/-) mice are osteoporotic and display increased perinatal mortality, reduced fertility, foreshortened crania and defects in the maturation of B cells in bone marrow. At least two mRNA isoforms have been reported, 6- or 7-kb, with alternatively spliced first exons joined to the common exons 2-11. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to malignant transformation. Further, a very long intron in the ABL1 gene is a target for translocations. Translocations of ABL1 to the breakpoint cluster region (BCR) on chromosome 22 lead to chronic myeloid leukemia and acute lymphocytic leukemia.Synonyms: ABL1 antibody, ABL2 antibody, Abelson Murine Leukemia Viral Oncogene Homolog 1 antibody, Bcr/c abl oncogene protein antibody, JTK7 antibody, Transformation gene oncogene ABL antibody, c-ABL antibody, p150 antibody
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