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FLIP 抗体 (C-Term)

This anti-FLIP antibody is a 兔 多克隆 antibody detecting FLIP in WB, IF 和 IHC (fro). Suitable for 人 和 小鼠.
产品编号 ABIN318973
发货至: 中国

Quick Overview for FLIP 抗体 (C-Term) (ABIN318973)

抗原

See all FLIP (CFLAR) 抗体
FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

适用

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人, 小鼠

宿主

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克隆类型

  • 97
  • 15
多克隆

标记

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This FLIP antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 191-209, C-Term

    特异性

    This antibody recognises the apoptosis related protein designated FLIP (FLICE inhibitory protein).

    纯化方法

    Purified

    免疫原

    A peptide corresponding to aa191 - 209 at the C-terminus of human FLIP delta/FLIPs form.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry on frozen sections: 2g/mL. Western Blot: 1: 1000, detects bands of approximately 35 kDa and 25 kDa in Jurkat celllysates.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)

    储存液

    Sodium azide

    注意事项

    This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

    别名

    CFLAR / Casper / I-FLICE

    背景

    FLIP interacts with the adaptor protein FADD, and with Caspase-8 (FLICE) and Caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1. FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. AHP1591 recognizes human and murine delta and gamma variants but not the alpha or beta, variants. FLIP is widely expressed in human tissues and a diverse range of cell lines.Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP

    基因ID

    8837

    NCBI登录号

    NP_001120655

    UniProt

    O15519

    途径

    Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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