JAK1 抗体 (pTyr1022)
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- 抗原 See all JAK1 抗体
- JAK1 (Janus Kinase 1 (JAK1))
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抗原表位
- pTyr1022
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This JAK1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects endogenous levels of JAK1 pTyr1022 protein.
- 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product JAK1 Primary Antibody
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anti-Janus Kinase 1 (JAK1) (pTyr1022), (pTyr1023) antibody
JAK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 120-380) antibodyJAK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) antibodyJAK1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Janus Kinase 1 (JAK1) (pTyr1022) antibodyJAK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 960-1040) antibodyJAK1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 1020-1024) antibodyJAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 866-899), (C-Term) antibodyJAK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB43812 unconjugated
anti-Janus Kinase 1 (JAK1) antibodyJAK1 适用: 人, 大鼠 WB, IP 宿主: 小鼠 Monoclonal 7B1-B6-G7 unconjugated
anti-Janus Kinase 1 (JAK1) (AA 172-204), (N-Term) antibodyJAK1 适用: 人 WB 宿主: 兔 Polyclonal RB43809 unconjugated
anti-Janus Kinase 1 (JAK1) antibodyJAK1 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 小鼠 Monoclonal 7G6 unconjugated
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- 应用备注
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ELISA: 1/10000-1/20000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- JAK1 (Janus Kinase 1 (JAK1))
- 别名
- Tyrosine-Protein Kinase JAK1 (JAK1 产品)
- 别名
- JAK1A antibody, JAK1B antibody, JTK3 antibody, AA960307 antibody, C130039L05Rik antibody, wu:fb93e10 antibody, jak1 antibody, Janus kinase 1 antibody, tyrosine-protein kinase JAK1 antibody, JAK1 antibody, Jak1 antibody, jak1 antibody, LOC100286690 antibody
- 背景
- JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.Synonyms: JAK-1, JAK1A, JAK1B, Janus kinase 1
- 分子量
- approx. 132 kDa
- 基因ID
- 3716
- NCBI登录号
- NP_002218
- UniProt
- P23458
- 途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response
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