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Androgen Receptor 抗体 (pSer650)

The 兔 多克隆 anti-Androgen Receptor antibody is suitable to detect Androgen Receptor in samples from 人. It has been validated for IHC (p).
产品编号 ABIN317960
发货至: 中国
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Quick Overview for Androgen Receptor 抗体 (pSer650) (ABIN317960)

抗原

See all Androgen Receptor (AR) 抗体
Androgen Receptor (AR)

适用

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克隆类型

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多克隆

标记

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This Androgen Receptor antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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    pSer650

    特异性

    P-Androgen Receptor (pSer650) antibody detects endogenous levels of p-Androgen Receptor protein.

    纯化方法

    Affinity chromatography
  • 应用备注

    ELISA: 1: 20000approx. 1: 40000. IHC: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1,0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    Androgen Receptor (AR)

    别名

    Androgen Receptor

    背景

    Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of liganddependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about three times more rapid than those of DHT. This difference in binding kinetic may account for the different physiological effects of T and DHT. Androgen binding results in an at least six-fold increase in androgen receptor stability. Akt phosphorylates human AR at Serines 210 and 790. The synthetic androgen R1881 elevates phosphorylation of Serines 308 and 650 in vitro.Synonyms: DHTR, Dihydrotestosterone receptor, NR3C4, Nuclear receptor subfamily 3 group C member 4

    基因ID

    367

    NCBI登录号

    NP_000035

    UniProt

    P10275

    途径

    Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
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