Androgen Receptor 抗体 (pSer650)
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Quick Overview for Androgen Receptor 抗体 (pSer650) (ABIN317960)
抗原
See all Androgen Receptor (AR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer650
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特异性
- P-Androgen Receptor (pSer650) antibody detects endogenous levels of p-Androgen Receptor protein.
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纯化方法
- Affinity chromatography
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应用备注
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ELISA: 1: 20000approx. 1: 40000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Androgen Receptor (AR)
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别名
- Androgen Receptor
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背景
- Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of liganddependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about three times more rapid than those of DHT. This difference in binding kinetic may account for the different physiological effects of T and DHT. Androgen binding results in an at least six-fold increase in androgen receptor stability. Akt phosphorylates human AR at Serines 210 and 790. The synthetic androgen R1881 elevates phosphorylation of Serines 308 and 650 in vitro.Synonyms: DHTR, Dihydrotestosterone receptor, NR3C4, Nuclear receptor subfamily 3 group C member 4
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基因ID
- 367
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NCBI登录号
- NP_000035
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UniProt
- P10275
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途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
抗原
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